Bethesda has this weird (and lazy) habit of faking interior lighting placing omni-directional lights here and there that don't really match the light sources, and even more importantly, by setting high ambient lighting values for the imagespaces the result is some bland, irrealistic and not immersive interiors, and as a side effect, the high ambient lighting tends to illuminate the interior fog to a degree where it becomes distracting and weirdly blue-ish. Interiors Enhanced: fadingsignal strikes again with a mandatory mod (to me).
The most intense weather conditions can be a bit more taxing on your GPU but it's manageable. The mod is stable, polished, and from a reputable author ( fadingsignal). True Storms: improves the looks of a lot of weather conditions, mostly precipitations and radstorms also adds a few new cool ones, and overhauls the fog effect. Unfortunately there isn't really much around for Fallout 4, but here's a few I can dig: